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Journal of Clinical Microbiology, June 2003, p. 2758-2759, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2758-2759.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Plasma versus Serum for Detection of Herpes Simplex Virus Type 2-Specific Immunoglobulin G Antibodies with a Glycoprotein G2-Based Enzyme Immunoassay

Thomas L. Cherpes,1,2* Leslie A. Meyn,3 and Sharon L. Hillier2,3

Department of Medicine, Division of Infectious Disease,1 Department of Obstetrics, Gynecology, and Reproductive Sciences,3 Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania2

Received 6 December 2002/ Returned for modification 17 January 2003/ Accepted 19 March 2003

To evaluate the consonance between plasma and serum for the detection of herpes simplex virus type 2-specific immunoglobulin G antibodies, we compared results from concurrently obtained plasma and sera in 710 sexually active women by using a glycoprotein G2-based enzyme-linked immunosorbent assay (Focus Technologies, Cypress, Calif.) and found 98.9% agreement between the two specimen types. Plasma appears to be an acceptable matrix for use with this assay.

* Corresponding author. Mailing address: Magee-Womens Research Institute, Room 540, 204 Craft Ave., Pittsburgh, PA 15213. Phone: (412) 641-1999. Fax: (412) 641-5290. E-mail: rsitc{at}mail.magee.edu.

Journal of Clinical Microbiology, June 2003, p. 2758-2759, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2758-2759.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • Chohan, V, Baeten, J M, Benki, S, Graham, S M, Lavreys, L, Mandaliya, K, Ndinya-Achola, J O, Jaoko, W, Overbaugh, J, McClelland, R S (2009). A prospective study of risk factors for herpes simplex virus type 2 acquisition among high-risk HIV-1 seronegative women in Kenya. Sex. Transm. Infect. 85: 489-492 [Abstract] [Full Text]  


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