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Journal of Clinical Microbiology, July 2003, p. 3339-3343, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3339-3343.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Comparison of Four Antimicrobial Susceptibility Testing Methods To Determine the In Vitro Activities of Piperacillin and Piperacillin-Tazobactam against Clinical Isolates of Enterobacteriaceae and Pseudomonas aeruginosa

James A. Karlowsky,1* Mellany K. Weaver,1 Clyde Thornsberry,1 Michael J. Dowzicky,2 Mark E. Jones,1 and Daniel F. Sahm1

Focus Technologies, Herndon, Virginia 20171,1 Wyeth Pharmaceuticals, Saint Davids, Pennsylvania 190872

Received 28 February 2003/ Returned for modification 27 March 2003/ Accepted 8 April 2003

Susceptibility to piperacillin was similar to that to piperacillin-tazobactam (<1% difference) for 6,938 isolates of Enterobacter aerogenes and 13,954 isolates of Enterobacter cloacae tested using a Vitek system; for the same species, in contrast, susceptibility rates to piperacillin-tazobactam were 5.9 to 13.9% higher than to piperacillin using disk diffusion, MicroScan, and Vitek 2 testing. Unprecedented phenotypes (piperacillin susceptible and piperacillin-tazobactam intermediate; piperacillin intermediate and piperacillin-tazobactam resistant; piperacillin susceptible and piperacillin-tazobactam resistant) accounted for 6.1% of the results for E. aerogenes isolates and 6.0% of the results for E. cloacae isolates tested with the Vitek system.

* Corresponding author. Mailing address: Focus Technologies, 13665 Dulles Technology Dr., Suite 200, Herndon, VA 20171-4603. Phone: (703) 480-2575. Fax: (703) 480-2654. E-mail: jkarlowsky{at}focusanswers.com.

Journal of Clinical Microbiology, July 2003, p. 3339-3343, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3339-3343.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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