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Journal of Clinical Microbiology, July 2003, p. 3395-3398, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3395-3398.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Cross-Reactivity of the PLATELIA CANDIDA Antigen Detection Enzyme Immunoassay with Fungal Antigen Extracts

Dagmar Rimek,1* Jagpal Singh,2 and Reinhard Kappe2

Department of Medical Microbiology and Hospital Hygiene, University Hospital, D-18057 Rostock,1 Institute of Medical Microbiology and Hygiene at the Helios Medical Center, D-99089 Erfurt, Germany2

Received 18 November 2002/ Returned for modification 18 January 2003/ Accepted 3 April 2003

We studied the specificity of the PLATELIA CANDIDA Ag enzyme immunoassay by using 130 isolates of 63 clinically relevant fungal species. Antigen extracts of seven Candida spp. (Candida albicans, C. dubliniensis, C. famata, C. glabrata, C. guilliermondii, C. lusitaniae, and C. tropicalis) repeatedly yielded positive reactions (>0.5 ng/ml). Geotrichum candidum and Fusarium verticillioides were found to yield borderline-positive reactions (0.25 to 0.50 ng/ml). Antigen preparations from the other 54 fungal species, including yeasts, molds, dermatophytes, and dimorphic fungi, did not cross-react in the assay.

* Corresponding author. Present address: TLLV, Department of Medical Microbiology, Nordhaeuser Str. 74, Haus 6, D-99089 Erfurt, Germany. Phone: 49-361-7409125. Fax: 49-361-7409111. E-mail: drimek{at}tllv.thueringen.de.

Journal of Clinical Microbiology, July 2003, p. 3395-3398, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3395-3398.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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