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Journal of Clinical Microbiology, July 2003, p. 3413-3414, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3413-3414.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Analysis of Clostridium difficile Strains Isolated from 18 Cases of Recurrent Clostridium difficile-Associated Diarrhea

Yajarayma Tang-Feldman, Susan Mayo, Joseph Silva, Jr., and Stuart H. Cohen*

Department of Internal Medicine, Division of Infectious and Immunologic Diseases, University of California, Davis Medical Center, Sacramento, California 95817

Received 2 December 2002/ Returned for modification 21 January 2003/ Accepted 30 March 2003

Recurrence of Clostridium difficile-associated diarrhea (CDAD) occurs in 15 to 20% of patients after discontinuation of treatment. Arbitrarily primed PCR was used to investigate the epidemiology of recurrent CDAD in 18 patients. Reinfection with a new strain occurred in 6 of 18 patients (33.3%), while 12 patients relapsed with the original strain shortly after discontinuation of treatment. These data suggest that reinfection with exogenous C. difficile is a common problem and that not all recurrences are due to relapse.

* Corresponding author. Mailing address: Division of Infectious and Immunologic Diseases, Dept. of Internal Medicine, Patient Services and Support Building, 4150 V St., Suite 500, Sacramento, CA 95817. Phone: (916) 734-3741. Fax: (916) 734-7766. E-mail: stcohen{at}ucdavis.edu.

Journal of Clinical Microbiology, July 2003, p. 3413-3414, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3413-3414.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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