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Journal of Clinical Microbiology, August 2003, p. 3873-3876, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3873-3876.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Identification of the Hypervirulent Lineages of Neisseria meningitidis, the ST-8 and ST-11 Complexes, by Using Monoclonal Antibodies Specific to NmeDI

Heike Claus, Hanne Weinand, Matthias Frosch, and Ulrich Vogel*

Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

Received 19 March 2003/ Returned for modification 7 May 2003/ Accepted 19 May 2003

Most cases of serogroup C meningococcal disease are caused by the clonal lineages ST-8 and ST-11. The gene encoding the putative restriction-modification system NmeDI is specific to these lineages. We report here a monoclonal antibody directed against the NmeDI endonuclease as a tool for their rapid and spe-cific identification.

* Corresponding author. Mailing address: Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Phone: 49 (931) 20146802. Fax: 49 (931) 20146445. E-mail: uvogel{at}hygiene.uni-wuerzburg.de.

Journal of Clinical Microbiology, August 2003, p. 3873-3876, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3873-3876.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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