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Journal of Clinical Microbiology, August 2003, p. 3936-3938, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3936-3938.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Strains of Streptococcus pyogenes from Severe Invasive Infections Bind HEp2 and HaCaT Cells More Avidly than Strains from Uncomplicated Infections

Mandy L Edwards,1,2 Peter K. Fagan,1,2 Heidi Smith-Vaughan,1 Bart J. Currie,1,2 and Kadaba S. Sriprakash1,2,3*

Menzies School of Health Research,1 Cooperative Research Centre for Aboriginal and Tropical Health, Darwin,2 Queensland Institute of Medical Research, Brisbane, Australia3

Received 20 March 2003/ Returned for modification 1 May 2003/ Accepted 6 May 2003

Epidemiologically unrelated Streptococcus pyogenes strains isolated from blood, throat, and skin were assayed for adherence to HEp2 and HaCaT cells. Invasive isolates showed significantly higher avidity for these cell lines than isolates from skin and throat. In general, S. pyogenes showed greater binding to HaCaT cells than to HEp2 cells.

* Corresponding author. Mailing address: Queensland Institute of Medical Research, 300 Herston Rd., Herston 4006, Australia. Phone: 61-7-33620407. Fax: 61-7-38453507. E-mail: sriS{at}qimr.edu.au.

Journal of Clinical Microbiology, August 2003, p. 3936-3938, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3936-3938.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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