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Journal of Clinical Microbiology, January 2004, p. 366-368, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.366-368.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Method for Testing for Human Papillomavirus Infection in Patients with Cervical Intraepithelial Disease

Hsing-Pei Lin,1 Yang-Yang Huang,1 Hsueh-Yin Wu,1 and Jau-Tsuen Kao2,3*

Department of Laboratory Medicine, Cathay General Hospital,1 Graduate Institute of Medical Technology, College of Medicine,2 Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan, Republic of China3

Received 18 June 2003/ Returned for modification 25 August 2003/ Accepted 23 September 2003

To determine whether DNA detection of high-risk human papillomavirus could represent a reliable screening technique and a useful follow-up method, we investigated the performance of the Hybrid Capture II assay in detecting high-grade cervical lesions. The test positivity at 1.86 pg/ml had a high sensitivity (94.7%) and improved specificity. It was also a suitable follow-up method for detecting the recurrence of cervical intraepithelial disease in patients.

* Corresponding author. Mailing address: Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100, Taiwan, ROC. Phone: (886) 2-23123456x6904. Fax: (886) 2-23711574. E-mail: jtkao{at}ha.mc.ntu.edu.tw.

Journal of Clinical Microbiology, January 2004, p. 366-368, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.366-368.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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