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Journal of Clinical Microbiology, January 2004, p. 426-430, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.426-430.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Prevalence of Human Immunodeficiency Virus Drug Resistance Mutations and Subtypes in Drug-Naive, Infected Individuals in the Army Health Service of Rio de Janeiro, Brazil

Ivone L. Pires,1 Marcelo A. Soares,2 Francisco A. B. Speranza,1 Solange K. Ishii,1 Maria C. G. Vieira,3 Maria I. F. S. Gouvêa,3 Maria A. A. M. Guimarães,4 Fátima E. de Oliveira,1 Monica M. F. Magnanini,5 Rodrigo M. Brindeiro,2 and Amilcar Tanuri2*

Seção de Virologia, Instituto de Biologia do Exército,1 Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro,2 Doenças Infecto-Parasitárias, Hospital Geral do Exército,3 Laboratório de Virologia, Hospital Universitário Clementino Fraga Filho,4 Núcleo de Estudos de Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil5

Received 15 April 2003/ Returned for modification 10 July 2003/ Accepted 26 September 2003

The prevalence of mutations that confer resistance to antiretroviral drugs was examined in 56 drug-naive, human immunodeficiency virus type 1 (HIV-1)-infected individuals from the Army Health Service in Rio de Janeiro, Brazil. No primary protease inhibitor mutations were found, but secondary mutations were observed in 51.2% of the samples. Fourteen percent of the viruses had reverse transcriptase inhibitor-associated mutations. Comparative analysis of protease secondary mutations from four different time periods in drug-naive patients in the city of Rio de Janeiro has indicated constant rates for particular mutations. Changes in CD4 cell counts and HIV viral load over time in subtype B- and non-B-infected drug-naive patients were not significantly different.

* Corresponding author. Mailing address: Laboratorio de Virologia Molecular, Departmanto de Genetica, Universidade Federal do Rio de Janeiro, CCS-Bl. A-sala A2-121, Cidade Universitaria—Ilha do Fundao, Rio de Janeiro RJ 21944-970, Brazil. Phone: 55-21-2562-6385. Fax: 55-21-2562-6397. E-mail: atanuri{at}biologia.ufrj.br.

Journal of Clinical Microbiology, January 2004, p. 426-430, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.426-430.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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