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Journal of Clinical Microbiology, January 2004, p. 435-438, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.435-438.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Efficacy of Galactomannan Antigen in the Platelia Aspergillus Enzyme Immunoassay for Diagnosis of Invasive Aspergillosis in Liver Transplant Recipients

Eun Jeong Kwak,1 Shahid Husain,1 Asia Obman,2 Lisa Meinke,2 Janet Stout,2 Shimon Kusne,1 Marilyn M. Wagener,2 and Nina Singh1,2*

Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center,1 Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 152402

Received 28 July 2003/ Returned for modification 29 September 2003/ Accepted 2 October 2003

The utility of galactomannan antigen for diagnosing invasive aspergillosis was evaluated in 154 liver transplant recipients. Sample agreement was 98.5%, and patient specificity was 87%. Galactomannan positivity correlated with mortality, even when controlled for the number of tests performed. Whether galactomannan positivity identifies a subgroup at risk for poor outcome warrants further evaluation.

* Corresponding author. Mailing address: Infectious Disease Section, VA Medical Center, University Dr. C, Pittsburgh, PA 15240. Phone: (412) 688-6179. Fax: (412) 688-6950. E-mail: nis5\|[plus ]\|{at}pitt.edu.

Journal of Clinical Microbiology, January 2004, p. 435-438, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.435-438.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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