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Journal of Clinical Microbiology, October 2004, p. 4846-4849, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4846-4849.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

icaA Is Not a Useful Diagnostic Marker for Prosthetic Joint Infection

Kristi L. Frank,1 Arlen D. Hanssen,2,3 and Robin Patel1,3,4*

Department of Biochemistry and Molecular Biology,1 Department of Orthopedic Surgery,2 Division of Infectious Diseases and Department of Medicine,3 Division of Clinical Microbiology and Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota4

Received 3 March 2004/ Returned for modification 13 April 2004/ Accepted 6 July 2004

A collection of 99 staphylococcal isolates associated with prosthetic joint infection and 23 coagulase-negative staphylococci isolated from noninfected arthroplasty-associated specimens were screened in order to determine whether the presence of icaA could be used to distinguish between pathogens and nonpathogens. All Staphylococcus aureus prosthetic joint infection isolates (n = 55) were icaA positive. A total of 46% (20 out of 44) of coagulase-negative staphylococcal prosthetic joint infection isolates were icaA positive, and 30% (7 out of 23) of arthroplasty-associated non-prosthetic joint infection-associated coagulase-negative staphylococcal isolates were icaA positive (P = 0.23). Certain coagulase-negative Staphylococcus species appeared more likely to be isolated as either arthroplasty-associated non-prosthetic joint infection-associated isolates (e.g., Staphylococcus warneri and Staphylococcus hominis) or pathogens (e.g., Staphylococcus lugdunensis). The presence of icaA in a coagulase-negative staphylococcal isolate associated with an arthroplasty is not a useful diagnostic indicator of pathogenicity.

* Corresponding author. Mailing address: Division of Infectious Diseases and Department of Medicine, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905. Phone: (507) 255-6482. Fax: (507) 255-7767. E-mail: patel.robin{at}mayo.edu.

Journal of Clinical Microbiology, October 2004, p. 4846-4849, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4846-4849.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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