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Journal of Clinical Microbiology, October 2004, p. 4856-4858, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4856-4858.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility of Helicobacter pylori Strains Isolated in Bangladesh

Shamsun Nahar,1 Asish K. Mukhopadhyay,2 Rasel Khan,1 Mian Mashhud Ahmad,3 Simanti Datta,2 Santanu Chattopadhyay,2 Swapan Chandra Dhar,3 Shafiqul Alam Sarker,1 Lars Engstrand,4 Douglas E. Berg,5 G. Balakrish Nair,1 and Motiur Rahman1*

International Centre for Diarrhoeal Disease Research,1 Dhaka Medical College Hospital, Dhaka, Bangladesh,3 National Institute of Cholera and Enteric Disease, Calcutta, India,2 SMI, Stockholm, Sweden,4 Departments of Molecular Microbiology and Genetics, Washington University School of Medicine, St. Louis, Missouri5

Received 25 March 2004/ Returned for modification 28 April 2004/ Accepted 18 May 2004

Antimicrobial susceptibility of 120 Helicobacter pylori isolates to metronidazole, tetracycline, clarithromycin, and amoxicillin was determined, and 77.5, 15, 10, and 6.6% of the isolates, respectively, were resistant. Only rdxA inactivation and both rdxA and frxA inactivation were responsible for metronidazole resistance in 66% (8 of 12) and 33% (4 of 12) of the isolates, respectively.

* Corresponding author. Mailing address: Laboratory Sciences Division, ICDDR, B, GPO Box-128, Dhaka-1000, Bangladesh. Phone: 871751-60. Fax: 880-2-872529/880-2-883116. E-mail: motiur{at}icddrb.org.

Journal of Clinical Microbiology, October 2004, p. 4856-4858, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4856-4858.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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