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Journal of Clinical Microbiology, November 2004, p. 5070-5075, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5070-5075.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of Cannomys badius as a Natural Animal Host of Penicillium marneffei in India

Harish Gugnani,1 Matthew C. Fisher,2* Anubha Paliwal-Johsi,1 Nongnuch Vanittanakom,3 Irabanta Singh,4 and Pratap Singh Yadav4

Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi,1 Department of Life Sciences, Manipur University, Imphal, Manipur, India,4 Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom,2 Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand3

Received 23 April 2004/ Returned for modification 2 June 2004/ Accepted 29 June 2004

Infection by Penicillium marneffei in human immunodeficiency virus-positive patients in India has recently been described; the aim of our study was to survey wild rodents and their associated environment in order to identify the natural populations of this fungus. Surveys recovered P. marneffei from the internal organs of 10 (9.1%) of 110 bamboo rats (Cannomys badius) examined from Manipur state, India, an area endemic for penicilliosis marneffei. Identification of the isolates was based on a detailed study of their morphological characteristics, in vitro conversion to fission yeast form, and exoantigen tests. Multilocus microsatellite typing (MLMT) of the isolates revealed five genotypes. No genotypes were shared between sample sites, and all bamboo rats were infected with a single genotype within sample sites, demonstrating spatial genetic heterogeneity. One MLMT genotype was identical to that seen in a human isolate, suggesting that either coinfection from a common source or host-to-host transmission had occurred. This demonstrates the utility of an MLMT-based approach to elucidating the epidemiology of P. marneffei.

* Corresponding author: Mailing address: Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom W2 1PG. Phone: 44 020 75943787. Fax: 44 207 5943693. E-mail: matthew.fisher{at}imperial.ac.uk.

Journal of Clinical Microbiology, November 2004, p. 5070-5075, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5070-5075.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lasker, B. A. (2006). Nucleotide Sequence-Based Analysis for Determining the Molecular Epidemiology of Penicillium marneffei.. J. Clin. Microbiol. 44: 3145-3153 [Abstract] [Full Text]  
  • Vanittanakom, N., Cooper, C. R. Jr., Fisher, M. C., Sirisanthana, T. (2006). Penicillium marneffei Infection and Recent Advances in the Epidemiology and Molecular Biology Aspects. Clin. Microbiol. Rev. 19: 95-110 [Abstract] [Full Text]  


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