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Journal of Clinical Microbiology, November 2004, p. 5264-5269, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5264-5269.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Occurrence of Extended-Spectrum ß-Lactamases in Members of the Genus Shigella in the Republic of Korea

Seonghan Kim,1 Junyoung Kim,1 Yeonho Kang,1 Yongkeun Park,2 and Bokkwon Lee1*

Laboratory of Enteric Infections, Department of Microbiology, National Institute of Health Korea,1 Graduate School of Biotechnology, Korea University, Seoul, Republic of Korea2

Received 16 January 2004/ Returned for modification 5 March 2004/ Accepted 19 July 2004

A nationwide survey was carried out in Korea to assess the prevalence of Shigella strains producing extended-spectrum ß-lactamases (ESBLs). From 1991 to 2002, 5,911 clinical strains were isolated and screened for resistance to extended-spectrum cephalosporins. Twenty of the Shigella isolates were ESBL positive, based on the synergistic effects between clavulanate and selected ß-lactams (ceftazidime and cefotaxime). Nucleotide sequence analysis of these isolates revealed that they harbored blaTEM-19 (eight isolates), blaTEM-15 (five isolates), blaTEM-52 (six isolates), blaTEM-17 (one isolate), blaTEM-20 (one isolate), and blaCTX-M-14 (three isolates). All the ESBL-encoding genes in this study were carried in conjugable plasmids. Thus, TEM-19, TEM-15, TEM-52, and CTX-M-14 ß-lactamases can be considered common Korean ESBL types in Shigella sonnei and are probably transmitted through interspecies spread between medical facilities and the community in Korea. This is the first report of the presence of TEM-17, TEM-19, and TEM-20 in Korea and in S. sonnei.

* Corresponding author. Mailing address: Laboratory of Enteric Infections, Department of Microbiology, National Institute of Health, 5 Nokbeon-dong, Eunpyeong-gu, Seoul, Republic of Korea, 122-701. Phone: 82-2-380-1462. Fax: 82-2-352-4767. E-mail: kkingsh{at}chol.com.

Journal of Clinical Microbiology, November 2004, p. 5264-5269, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5264-5269.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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