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Journal of Clinical Microbiology, November 2004, p. 5345-5348, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5345-5348.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mycobacterium avium subsp. paratuberculosis Strains Isolated from Crohn's Disease Patients and Animal Species Exhibit Similar Polymorphic Locus Patterns

Alifiya H. Ghadiali,1 Megan Strother,1 Saleh A. Naser,2 Elizabeth J. B. Manning,3 and Srinand Sreevatsan1*

Food Animal Health Research Program, Ohio Agricultural Research Development Center and Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, Ohio,1 Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida,2 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin3

Received 29 May 2004/ Returned for modification 19 July 2004/ Accepted 2 August 2004

Analysis of short sequence repeats of Mycobacterium avium subsp. paratuberculosis isolated from Crohn's disease patients identified two alleles, both of which clustered with strains derived from animals with Johne's disease. Identification of a limited number of genotypes among human strains implies the existence of human disease-associated genotypes and strain sharing with animals.

* Corresponding author. Mailing address: FAHRP-OARDC, The Ohio State University, 1680 Madison Ave., Wooster, OH 44691. Phone: (330) 263-3744. Fax: (330) 263-3677. E-mail: sreevatsan.1{at}osu.edu.

Journal of Clinical Microbiology, November 2004, p. 5345-5348, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5345-5348.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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