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Journal of Clinical Microbiology, November 2004, p. 5362-5363, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5362-5363.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

False-Positive Aspergillus Galactomannan Enzyme-Linked Immunosorbent Assay Results In Vivo during Amoxicillin-Clavulanic Acid Treatment

Daniele Mattei,1* Davide Rapezzi,1 Nicola Mordini,1 Federica Cuda,1 Cristiana Lo Nigro,2 Maura Musso,2 Aldo Arnelli,3 Sebastiano Cagnassi,4 and Andrea Gallamini1

Departments of Hematology,1 Laboratory,2 Pharmacy, Santa Croce Hospital, Cuneo,4 Department of Laboratory, Santissima Annunziata Hospital, Savigliano, Italy3

Received 1 June 2004/ Returned for modification 23 June 2004/ Accepted 11 August 2004

Positive Platelia Aspergillus test results were observed in consecutive serum samples from an immunocompromised host during amoxicillin-clavulanic acid treatment, and a correlation between plasmatic amoxicillin concentration and galactomannan optical density index was observed. Amoxicillin-clavulanic acid vials tested positive for galactomannan but were negative for Aspergillus DNA.

* Corresponding author. Mailing address: Department of Hematology, S. Croce Hospital, Via Michele Coppino 26, 12100 Cuneo, Italy. Phone: 39-0171-641070. Fax: 39-0171-699545. E-mail: daealemattei{at}tin.it.

Journal of Clinical Microbiology, November 2004, p. 5362-5363, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5362-5363.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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