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Journal of Clinical Microbiology, November 2004, p. 5364-5367, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5364-5367.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Polymorphisms of the Fimbria fim3 Gene of Bordetella pertussis Strains Isolated in Canada

Raymond S. W. Tsang,1* Allan K. H. Lau,1 Michelle L. Sill,1 Scott A. Halperin,2 Paul Van Caeseele,3 Frances Jamieson,4 and Irene E. Martin1

Vaccine Preventable Bacterial Diseases Division, National Microbiology Laboratory, Population and Public Health Branch, Health Canada,1 Cadham Provincal Laboratory, Manitoba Health, Winnipeg, Manitoba,3 Department of Microbiology, Immunology and Pediatric Infectious Diseases, Dalhousie University, Halifax, Nova Scotia,2 Ontario Public Health Laboratory, Ministry of Health and Long Term Care, Toronto, Ontario, Canada4

Received 19 January 2004/ Returned for modification 29 February 2004/ Accepted 23 June 2004

The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.

* Corresponding author. Mailing address: National Microbiology Laboratory, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-6020. Fax: (204) 789-2018. E-mail: rtsang{at}hc-sc.gc.ca.

Journal of Clinical Microbiology, November 2004, p. 5364-5367, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5364-5367.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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