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Journal of Clinical Microbiology, December 2004, p. 5842-5845, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5842-5845.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Azithromycin Retards Pseudomonas aeruginosa Biofilm Formation

Richard J. Gillis and Barbara H. Iglewski*

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Received 14 June 2004/ Returned for modification 2 August 2004/ Accepted 23 August 2004

Using a flow cell biofilm model, we showed that a sub-MIC of azithromycin (AZM) can delay but not inhibit Pseudomonas aeruginosa biofilm formation and results in the development of a stable AZM resistance phenotype. Furthermore, mature biofilms were not affected by AZM.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Box 672, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642. Phone: (585) 275-3402. Fax: (585) 473-9573. E-mail: bigl{at}mail.rochester.edu.

Journal of Clinical Microbiology, December 2004, p. 5842-5845, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5842-5845.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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