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Journal of Clinical Microbiology, December 2004, p. 5904-5908, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5904-5908.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Characterization of Hemolytic Escherichia coli Strains in Ferrets: Recognition of Candidate Virulence Factor CNF1

Robert P. Marini,1 Nancy S. Taylor,1 Alvin Y. Liang,2 Kimberly A. Knox,1,2 Jeremy Andrew Peña,3 David B. Schauer,1,2 and James G. Fox1,2*

Division of Comparative Medicine,1 Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts,2 Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas3

Received 22 January 2004/ Returned for modification 6 May 2004/ Accepted 31 July 2004

Diseases associated with Escherichia coli infection are the subject of renewed interest due to emerging conditions such as hemolytic uremia syndrome. A collection of 15 strains of beta-hemolytic E. coli was isolated from diarrheic feces and diseased tissues of ferrets. All 15 strains were positive in specific PCR assays for the presence of hlyA, pap1, and cnf1. Seven of the cnf1-positive isolates were tested and shown to have a cytopathic effect on HeLa cell monolayers. The pathogenesis of these strains warrants future study.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139. Phone: (617) 253-3050. Fax: (617) 258-5708. E-mail: jgfox{at}mit.edu.

Journal of Clinical Microbiology, December 2004, p. 5904-5908, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5904-5908.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Martin, H. R., Taylor, N. S., Buckley, E. M., Marini, R. P., Patterson, M. M., Fox, J. G. (2009). Characterization of cytotoxic necrotizing factor 1-producing Escherichia coli strains from faeces of healthy macaques. J Med Microbiol 58: 1354-1358 [Abstract] [Full Text]  
  • Perpinan, D., Ramis, A., Tomas, A., Carpintero, E., Bargallo, F. (2008). Outbreak of canine distemper in domestic ferrets (Mustela putorius furo). Vet Rec. 163: 246-250 [Abstract] [Full Text]  


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