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Journal of Clinical Microbiology, December 2004, p. 5938-5939, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5938-5939.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Molecular Characterization of Fluconazole Resistance in a Case of Candida albicans Ocular Infection

Preeti Pancholi,1* Steven Park,2 David Perlin,2 Christine Kubin,3 and Phyllis Della-Latta1

Clinical Microbiology Laboratory, Department of Pathology,1 Department of Pharmacy and Division of Infectious Diseases, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York,3 Public Health Research Institute, Newark, New Jersey2

Received 30 March 2004/ Returned for modification 13 June 2004/ Accepted 19 June 2004

Ocular yeast infections in diabetics are a therapeutic challenge. Drug resistance and reduced azole susceptibility are major concerns. The case we describe characterizes a Candida albicans strain from a vitrectomy specimen that was susceptible to fluconazole by in vitro testing but recalcitrant to therapy. Molecular studies revealed transient overexpression of CDR1 and ERG11 mRNA in the presence of fluconazole that may have contributed to poor clinical response in this patient.

* Corresponding author. Mailing address: Columbia University Medical Center, 622 West 168th St., CHS 3-326, New York, NY 10032. Phone: (212) 305-6237. Fax: (212) 305-8971. E-mail: prp9005{at}nyp.org.

Journal of Clinical Microbiology, December 2004, p. 5938-5939, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5938-5939.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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