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Journal of Clinical Microbiology, February 2004, p. 891-894, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.891-894.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Genotypic and Phenotypic Characterization of Drug-Resistant Mycobacterium tuberculosis Isolates from Rural Districts of the Western Cape Province of South Africa

E. M. Streicher,1 R. M. Warren,1 C. Kewley,2 J. Simpson,3 N. Rastogi,4 C. Sola,4 G. D. van der Spuy,1 P. D. van Helden,1 and T. C. Victor1*

MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg,1 Brewelskloof Hospital, Worcester,2 National Health Laboratory Services, Cape Town, South Africa,3 Institut Pasteur de Guadeloupe, Pointe à Pitre, Guadeloupe, France4

Received 12 June 2003/ Returned for modification 1 September 2003/ Accepted 22 October 2003

Genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberculosis isolates from the Western Cape Province of South Africa showed that drug resistance is widespread and recently transmitted. Multidrug-resistant (MDR) isolates comprise 40% of this collection, and a large pool of isoniazid monoresistance may be a future source of MDR tuberculosis.

* Corresponding author. Mailing address: MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 27-21-9389251. Fax: 27-21-9389476. E-mail: tv{at}sun.ac.za.

Journal of Clinical Microbiology, February 2004, p. 891-894, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.891-894.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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