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Journal of Clinical Microbiology, February 2004, p. 899-902, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.899-902.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Two Microdilution Methods for Testing Susceptibility of Candida spp. to Voriconazole

Maria José Linares,* Guadalupe Charriel, Francisco Solís, and Manuel Casal

Department of Microbiology, Faculty of Medicine, University of Córdoba, 14004 Córdoba, Spain

Received 8 July 2003/ Returned for modification 29 July 2003/ Accepted 30 October 2003

The growing number of fungal infections, coupled with emerging resistance to classical antifungal agents, has led to the development of new agents, among them voriconazole. Susceptibility to voriconazole was tested by using two microdilution techniques: the reference method described in National Committee for Clinical Laboratory Standards document M27-A2 and a colorimetric method, Sensititre YeastOne. A total of 272 Candida isolates (132 of Candida albicans, 62 of C. parapsilosis, 33 of Candida glabrata, 21 of C. krusei, 15 of C. tropicalis, and 9 of C. lusitaniae) and two control strains (C. parapsilosis ATCC 22019 and C. krusei ATCC 6258) were tested. There was a high rate of agreement between the two methods used (97 to 100%).

* Corresponding author. Mailing address: Departamento de Microbiología, Facultad de Medicina, Avda. Menendez Pidal S/N, 14004 Córdoba, Spain. Phone: 345-957-218286. Fax: 34-957-218229. E-mail: millisim{at}uco.es.

Journal of Clinical Microbiology, February 2004, p. 899-902, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.899-902.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Linares, M. J., Solis, F., Casal, M. (2005). In Vitro Activity of Voriconazole against Prototheca wickerhamii: Comparative Evaluation of Sensititre and NCCLS M27-A2 Methods of Detection. J. Clin. Microbiol. 43: 2520-2522 [Abstract] [Full Text]  
  • Linares, M. J., Charriel, G., Solis, F., Rodriguez, F., Ibarra, A., Casal, M. (2005). Susceptibility of Filamentous Fungi to Voriconazole Tested by Two Microdilution Methods. J. Clin. Microbiol. 43: 250-253 [Abstract] [Full Text]  


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