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Journal of Clinical Microbiology, February 2004, p. 929-932, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.929-932.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Treatment of Meningitis Due to Methicillin-Resistant Staphylococcus epidermidis with Linezolid

Wolfgang A. Krueger,1* Bernd Kottler,1 Bernd E. Will,2 Alexandra Heininger,1 Heinz Guggenberger,1 and Klaus E. Unertl1

Department of Anesthesiology and Intensive Care Medicine,1 Department of Neurosurgery, Tübingen University Hospital, 72076 Tübingen, Germany2

Received 20 June 2003/ Returned for modification 18 September 2003/ Accepted 4 November 2003

Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.

* Corresponding author. Mailing address: Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. Phone: 49-7071-298-6622. Fax: 49-7071-29-5533. E-mail: wolfgang.krueger{at}uni-tuebingen.de.

Journal of Clinical Microbiology, February 2004, p. 929-932, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.929-932.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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  • Myrianthefs, P., Markantonis, S. L., Vlachos, K., Anagnostaki, M., Boutzouka, E., Panidis, D., Baltopoulos, G. (2006). Serum and Cerebrospinal Fluid Concentrations of Linezolid in Neurosurgical Patients. Antimicrob. Agents Chemother. 50: 3971-3976 [Abstract] [Full Text]  
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