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Journal of Clinical Microbiology, March 2004, p. 1203-1206, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1203-1206.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antibiotic-Associated Diarrhea Accompanied by Large-Scale Alterations in the Composition of the Fecal Microbiota

Vincent B. Young1,2,3* and Thomas M. Schmidt1

Department of Microbiology and Molecular Genetics,1 and Department of Internal Medicine, Infectious Diseases Unit,2 National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 488243

Received 1 May 2003/ Returned for modification 8 September 2003/ Accepted 14 November 2003

Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document temporal changes in the diversity of fecal bacteria of a patient who developed AAD. Antibiotic administration was associated with distinct changes in the diversity of the gut microbiota, including a marked decrease in the prevalence of butyrate-producing bacteria. Following the discontinuation of the antibiotic, resolution of diarrhea was accompanied by a reversal of these changes, providing the first direct evidence linking changes in the community structure of the gastrointestinal bacteria with the development of AAD.

* Corresponding author. Mailing address: Room B42 Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824. Phone: (517) 432-3100. Fax: (517) 432-2310. E-mail: youngvi{at}msu.edu.

Journal of Clinical Microbiology, March 2004, p. 1203-1206, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1203-1206.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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