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Journal of Clinical Microbiology, March 2004, p. 1294-1295, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1294-1295.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison,1* Salman H. Siddiqi,2 Leonid Heifets,3 Wendy Gross,4 Mike Higgins,3 Nancy Warren,5,{dagger} Anthony Thompson,5 Glenn Morlock,6 and John C. Ridderhof1

Division of Laboratory Systems, Public Health Practice Program Office,1 National Center for HIV, STD and TB Prevention, Centers for Disease ControlPrevention, Atlanta, Georgia,6 Becton Dickinson Microbiology Systems, Sparks, Maryland 21152,2 National Jewish Medical and Research Center, Denver, Colorado 80206,3 VA TB Reference Laboratory, West Haven, Connecticut 06516,4 Laboratory Corporation of America, Burlington, North Carolina 272155

Received 1 August 2003/ Returned for modification 27 October 2003/ Accepted 17 November 2003

We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) -> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.

* Corresponding author. Mailing address: Office Division of Laboratory Systems, Public Health Practice Program, Centers for Disease Control and Prevention, 4770 Buford Highway, N.E., MS G-25, Atlanta, GA 30341. Phone: (770) 488-8133. Fax: (770) 488-8282. E-mail: bdm6{at}cdc.gov.

{dagger} Present address: Bureau of Laboratories, Pennsylvania Department of Health, Lionville, Pa.

Journal of Clinical Microbiology, March 2004, p. 1294-1295, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1294-1295.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Guo, H., Seet, Q., Denkin, S., Parsons, L., Zhang, Y. (2006). Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA.. J Med Microbiol 55: 1527-1531 [Abstract] [Full Text]  
  • Vilcheze, C., Weisbrod, T. R., Chen, B., Kremer, L., Hazbon, M. H., Wang, F., Alland, D., Sacchettini, J. C., Jacobs, W. R. Jr. (2005). Altered NADH/NAD+ Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria. Antimicrob. Agents Chemother. 49: 708-720 [Abstract] [Full Text]  


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