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Journal of Clinical Microbiology, March 2004, p. 1322-1325, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1322-1325.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

First Molecular Identification of Human Dobrava Virus Infection in Central Europe

Boris Klempa,1,2 Morten Schütt,3 Brita Auste,1 Milan Labuda,4 Rainer Ulrich,1 Helga Meisel,1 and Detlev H. Krüger1*

Institute of Virology, University Hospital Charité, D-10098 Berlin,1 Department of Internal Medicine I, University Hospital, D-23538 Lübeck, Germany,3 Institute of Virology,2 Institute of Zoology, Slovak Academy of Sciences, SK-84206 Bratislava, Slovakia3

Received 4 September 2003/ Returned for modification 9 November 2003/ Accepted 14 December 2003

Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava hantavirus (DOBV). This is the first molecular identification of human infection by DOBV in central Europe and the first proof that a virus strain related to the DOBV-Aa lineage, carried by Apodemus agrarius rodents, is able to cause HFRS.

* Corresponding author. Mailing address: Institute of Virology, University Hospital Charité, D-10098 Berlin, Germany. Phone: 49-30-450 525 092. Fax: 49-30-450 525 907. E-mail: detlev.kruger{at}charite.de.

Journal of Clinical Microbiology, March 2004, p. 1322-1325, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1322-1325.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Meisel, H., Wolbert, A., Razanskiene, A., Marg, A., Kazaks, A., Sasnauskas, K., Pauli, G., Ulrich, R., Kruger, D. H. (2006). Development of Novel Immunoglobulin G (IgG), IgA, and IgM Enzyme Immunoassays Based on Recombinant Puumala and Dobrava Hantavirus Nucleocapsid Proteins. CVI 13: 1349-1357 [Abstract] [Full Text]  
  • Plyusnin, A., Vaheri, A., Lundkvist, A., Klempa, B., Meisel, H., Kruger, D. H., Ulrich, R., Stanko, M., Labuda, M. (2006). Saaremaa Hantavirus Should Not Be Confused with Its Dangerous Relative, Dobrava Virus. J. Clin. Microbiol. 44: 1608-1611 [Full Text]  
  • Klempa, B., Stanko, M., Labuda, M., Ulrich, R., Meisel, H., Kruger, D. H. (2005). Central European Dobrava Hantavirus Isolate from a Striped Field Mouse (Apodemus agrarius). J. Clin. Microbiol. 43: 2756-2763 [Abstract] [Full Text]  


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