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Journal of Clinical Microbiology, March 2004, p. 1341-1344, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1341-1344.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Papillomavirus, Cytomegalovirus, and Adeno-Associated Virus Infections in Pregnant and Nonpregnant Women with Cervical Intraepithelial Neoplasia

M. Grce,1* K. Husnjak,1 M. Matovina,1 N. Milutin,1 L. Magdic,2 O. Husnjak,3 and K. Pavelic1

Division of Molecular Medicine, Rudjer Boskovic Institute,1 Department of Obstetrics and Gynaecology, Medical School,2 Department of Physics, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia3

Received 26 July 2003/ Returned for modification 8 September 2003/ Accepted 17 November 2003

Two hundred eight cervical specimens from two groups of subjects, 165 nonpregnant women and 53 pregnant women with cervical intraepithelial neoplasia (CIN) of grades I to III, were positive by PCR analyses for human papillomaviruses (HPVs), adeno-associated virus type 2 (AAV 2), and human cytomegalovirus (HCMV) in 67, 6, and 4.1% of the cases, respectively. The presence of AAV 2 infection was more frequently associated with pregnancy (17 versus 2.4%) and HPV-positive cervices (odds ratio = 6.358) than HCMV was. Increased HPV infection was strongly associated (P < 0.001) with a higher CIN grade, but there is no evidence that AAV 2 and HCMV infections have any impact on CIN development.

* Corresponding author. Mailing address: Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka cesta 54, P.O.B. 180, HR-10002 Zagreb, Croatia. Phone: 385 1 456 11 10. Fax: 385 1 456 10 10. E-mail: grce{at}irb.hr.

Journal of Clinical Microbiology, March 2004, p. 1341-1344, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1341-1344.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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