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Journal of Clinical Microbiology, March 2004, p. 1345-1347, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1345-1347.2003
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Highly Conserved Alpha-Toxin Sequences of Avian Isolates of Clostridium perfringens

Scott A. Sheedy,1,2 Aaron B. Ingham,1 Julian I. Rood,2 and Robert J. Moore1,2*

Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220,1 Australian Research Council Centre for Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Geelong 3800, Australia2

Received 12 August 2003/ Returned for modification 13 September 2003/ Accepted 4 November 2003

Clostridium perfringens causes necrotic enteritis in chickens, and alpha-toxin has been suggested to be a key virulence determinant. Analysis of the alpha-toxin of 25 chicken-derived C. perfringens strains demonstrated high homology to mammal-derived strains rather than to the only avian-derived C. perfringens alpha-toxin sequence reported previously.

* Corresponding author. Mailing address: Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia. Phone: 61-3-52275000. Fax: 61-3-52275555. E-mail: Rob.Moore{at}csiro.au.

Journal of Clinical Microbiology, March 2004, p. 1345-1347, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1345-1347.2003
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ma, M., Ohtani, K., Shimizu, T., Misawa, N. (2007). Detection of a Group II Intron without an Open Reading Frame in the Alpha-Toxin Gene of Clostridium perfringens Isolated from a Broiler Chicken. J. Bacteriol. 189: 1633-1640 [Abstract] [Full Text]  
  • Keyburn, A. L., Sheedy, S. A., Ford, M. E., Williamson, M. M., Awad, M. M., Rood, J. I., Moore, R. J. (2006). Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens. Infect. Immun. 74: 6496-6500 [Abstract] [Full Text]  
  • Titball, R. W. (2005). Gas gangrene: an open and closed case. Microbiology 151: 2821-2828 [Full Text]  


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