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Journal of Clinical Microbiology, March 2004, p. 1356-1359, Vol. 42, No. 3
0095-1137/04/$08.00+0 DOI: 10.1128/JCM.42.3.1356-1359.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Cryptococcus neoformans Shows a Remarkable Genotypic Diversity in Brazil
M. T. Barreto de Oliveira,1 T. Boekhout,2,3 B. Theelen,2 F. Hagen,2 F. A. Baroni,4 M. S. Lazera,5 K. B. Lengeler,6 J. Heitman,7 I. N. G. Rivera,8 and C. R. Paula8*
Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal,1
Department of Microbiology and Immunology, University Rural of Rio de Janeiro,4
FIOCRUZ, Rio de Janeiro,5
Department of Microbiology, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil,8
Centraalbureau voor Schimmelcultures,2
Department of Medicine, University Medical Center, Utrecht, The Netherlands,3
Department of Microbiology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany,6
Duke University, Durham, North Carolina 277087
Received 23 April 2003/
Returned for modification 8 July 2003/
Accepted 9 October 2003
The genotypic diversity of Brazilian Cryptococcus neoformans strains was analyzed. The majority of the samples were
A (65%), followed by
B (17.5%),
D (9%),
AaD hybrids (5%), and
C (3.5%). A considerable genotypic diversity occurred within C. neoformans var. grubii, and a new amplified fragment length polymorphism genotype, 1B, was recognized.
* Corresponding author. Mailing address: Av. Prof. Lineu Prestes, 1374, Cidade UniversitáriaUSP, CEP 05508-900 São Paulo, Brazil. Phone: 551130917294. Fax: 551130917354. E-mail:
crpmicol{at}uol.com.br.
Journal of Clinical Microbiology, March 2004, p. 1356-1359, Vol. 42, No. 3
0095-1137/04/$08.00+0 DOI: 10.1128/JCM.42.3.1356-1359.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
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