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Journal of Clinical Microbiology, April 2004, p. 1846-1848, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1846-1848.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Culture-Negative Endocarditis Due to Houston Complex Bartonella henselae Acquired in Noumea, New Caledonia

Dani Rodrick,1 Belinda Dillon,2 Mark Dexter,1 Ian Nicholson,3 Sebastien Marcel,4 David Dickeson,5 and Jon Iredell2,6*

Westmead Private Hospital,1 Centre for Infectious Diseases and Microbiology,2 Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, Westmead Hospital,5 Children's Hospital Medical Centre, Westmead,3 University of Sydney, Sydney, New South Wales, Australia,6 Service de Neurologie, CHT Gaston Bourret, Nouméa, New Caledonia4

Received 13 August 2003/ Returned for modification 23 September 2003/ Accepted 23 October 2003

A 44-year-old man with a bioprosthetic aortic valve suffered destructive endocarditis with severe embolic disease due to Bartonella henselae infection. Multilocus sequence typing was successfully performed with crude preparations of operative tissue as templates, and the infecting organism was determined to be typical of the Houston clonal group, although it was never cultured from blood or tissue. This is the first report of B. henselae infection in the South Pacific, and it reminds one that B. henselae is a cause of potentially lethal culture-negative endocarditis which may respond poorly to conventional empirical therapy. Nothing is known of the epidemiology of the infection in this region, but it is likely to be common and to contain representatives of both major clonal complexes. This study emphasizes the ease with which multilocus sequence typing can be used directly with tissue, which is important because of suggestions of strain-dependent clinical outcomes.

* Corresponding author. Mailing address: University of Sydney, Centre for Infectious Diseases and Microbiology, Level 3, Institute for Clinical Pathology and Medical Research Building, Westmead Hospital, Sydney 2145, New South Wales, Australia. Phone: 61 2 9845 6255. Fax: 61 2 9891 5317. E-mail: joni{at}icpmr.wsahs.nsw.gov.au.

Journal of Clinical Microbiology, April 2004, p. 1846-1848, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1846-1848.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dabo, S. M., Confer, A. W., Anderson, B. E., Gupta, S. (2006). Bartonella henselae Pap31, an Extracellular Matrix Adhesin, Binds the Fibronectin Repeat III13 Module.. Infect. Immun. 74: 2513-2521 [Abstract] [Full Text]  
  • Dillon, B, Iredell, J (2004). DdeI RFLP for 16S rDNA typing in Bartonella henselae. J Med Microbiol 53: 1263-1265 [Full Text]  


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