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Journal of Clinical Microbiology, June 2004, p. 2495-2500, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2495-2500.2004

Molecular Epidemiologic Evaluation of Endocarditis Due to Oerskovia turbata and CDC Group A-3 Associated with Contaminated Homograft Valves

Michael M. McNeil,1,{dagger} June M. Brown,1* Michelle E. Carvalho,1 Dannie G. Hollis,1 Roger E. Morey,1 and L. Barth Reller2

Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 Clinical Microbiology Laboratory and Departments of Pathology and Medicine, Duke University School of Medicine, Durham, North Carolina 277102

Received 23 January 2004/ Returned for modification 8 March 2004/ Accepted 16 March 2004

Oerskovia turbata is an unusual bacterial cause of endocarditis and septicemia in immunocompromised patients. In this study, we compared 12 isolates from a 1975 medical center cluster, 11 originally identified as O. turbata (four from the blood of a homograft aortic valve-associated endocarditis patient and seven from contaminated homograft valves) and one CDC group A-3 strain from the blood of a second endocarditis patient with fatal outcome, with eight control strains from unrelated locations. The control strains included type and reference strains of O. turbata, Cellulomonas hominis, and CDC group A-3. The four blood isolates from the first patient and six of the valve isolates shared identical biochemical, antimicrobial susceptibility, and BglI ribotype patterns that differed from the second patient's isolate and control strains. The blood isolate from the second patient and the remaining valve isolate shared a phenotypic and genotypic profile and were phenotypically identical to, but epidemiologically different from, the CDC group A-3 reference strain with the strain-specific enzyme. Also, these isolates differed from the type strain and the other reference strains of C. hominis and O. turbata. Our results indicate that the four blood isolates from the first patient and six of the homograft valve isolates represent a single clone of O. turbata associated with endocarditis. Additionally, our results indicate that the blood isolate from the second patient and one of the homograft valve isolates differ from O. turbata and C. hominis and represent a unique clone of CDC group A-3 associated with fatal endocarditis.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, Mailstop G-34, Atlanta, GA 30333. Phone: (404) 639-3491. Fax: (404) 639-3022. E-mail: jmb6{at}cdc.gov.

{dagger} Present address: Division of Epidemiology and Surveillance, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333.

Journal of Clinical Microbiology, June 2004, p. 2495-2500, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2495-2500.2004




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