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Journal of Clinical Microbiology, June 2004, p. 2682-2684, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2682-2684.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Prevalence of Helicobacter pylori vacA and cagA Genotypes in Ethiopian Dyspeptic Patients

Daniel Asrat,1 Ingrid Nilsson,2 Yohannes Mengistu,1 Endale Kassa,3 Senait Ashenafi,4 Kiros Ayenew,5 Torkel Wadström,2 and Waleed Abu-Al-Soud2*

Department of Medical Microbiology, Immunology, and Parasitology,1 Department of Internal Medicine,3 Department of Pathology, Faculty of Medicine, Addis Ababa University,4 Armauer Hansen Research Institute, Addis Ababa, Ethiopia,5 Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden2

Received 1 December 2003/ Returned for modification 6 January 2004/ Accepted 18 February 2004

A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P < 0.05).

* Corresponding author. Mailing address: Department of Medical Microbiology, Dermatology and Infection, Lund University, Sölvegatan 23, SE-223 62 Lund, Sweden. Phone: 46 46 173298. Fax: 46 46 189117. E-mail: abu.al-soud{at}mmb.lu.se.

Journal of Clinical Microbiology, June 2004, p. 2682-2684, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2682-2684.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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