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Journal of Clinical Microbiology, June 2004, p. 2774-2776, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2774-2776.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR Test for Subjects with Low Viral Load

J. Brooks Jackson,1* Estelle Piwowar-Manning,1 LeTanya Johnson-Lewis,1 Roland Bassett,2 Lisa M. Demeter,3 and Donald Brambilla4

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287,1 SDAC, Harvard School of Public Health, Boston Massachusetts 02115-6017,2 University of Rochester Medical Center, Rochester, New York 14642,3 New England Research Institutes, Watertown, Massachusetts 024724

Received 8 October 2003/ Returned for modification 23 December 2003/ Accepted 9 March 2004

We compared the performance of two UltraSensitive AMPLICOR HIV-1 MONITOR kits (version 1.5 [v1.5] versus v1.0) by retesting 404 plasma samples with low viral loads (<3,000 copies/ml) with both kits. With 292 samples that initially had <50 copies/ml by the v1.0 kit, the v1.5 assay was more sensitive than the v1.0 assay for samples with human immunodeficiency virus type 1 RNA near the 50-copy/ml cutoff (P = 0.0146). Median numbers of copies per milliliter were similar for 112 samples with 50 to 3,000 copies/ml with no difference in sensitivity with a 200-copy/ml cutoff.

* Corresponding author. Mailing address: Johns Hopkins Medical Institutions, Carnegie Building, Room 415, 600 North Wolfe St., Baltimore, MD 21287. Phone: (410) 614-4966. Fax: (410) 614-2907. E-mail: bjackso{at}jhmi.edu.

Journal of Clinical Microbiology, June 2004, p. 2774-2776, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2774-2776.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Salimnia, H., Moore, E. C., Crane, L. R., MacArthur, R. D., Fairfax, M. R. (2005). Discordance between Viral Loads Determined by Roche COBAS AMPLICOR Human Immunodeficiency Virus Type 1 Monitor (Version 1.5) Standard and Ultrasensitive Assays Caused by Freezing Patient Plasma in Centrifuged Becton-Dickinson Vacutainer Brand Plasma Preparation Tubes. J. Clin. Microbiol. 43: 4635-4639 [Abstract] [Full Text]  
  • Nettles, R. E., Kieffer, T. L., Kwon, P., Monie, D., Han, Y., Parsons, T., Cofrancesco, J. Jr, Gallant, J. E., Quinn, T. C., Jackson, B., Flexner, C., Carson, K., Ray, S., Persaud, D., Siliciano, R. F. (2005). Intermittent HIV-1 Viremia (Blips) and Drug Resistance in Patients Receiving HAART. JAMA 293: 817-829 [Abstract] [Full Text]  
  • Brambilla, D. J., Jennings, C., Morack, R., Granger, S., Bremer, J. W. (2004). Comparison of the Sensitivities of the Version 1.5 and Version 1.0 Ultrasensitive Roche AMPLICOR HIV-1 MONITOR Kits at Low Concentrations of Human Immunodeficiency Virus RNA. J. Clin. Microbiol. 42: 2819-2820 [Abstract] [Full Text]  


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