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Journal of Clinical Microbiology, June 2004, p. 2806-2809, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2806-2809.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Survey of Ferroxidase Expression and Siderophore Production in Clinical Isolates of Pseudomonas aeruginosa

Wilhelmina M. Huston,1 Adam J. Potter,1 Michael P. Jennings,1* Jordi Rello,2 Alan R. Hauser,3,4 and Alastair G. McEwan1

Centre for Metals in Biology, Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, 4072 Queensland, Australia,1 Department of Microbiology and Immunology,3 Department of Medicine, Northwestern University, Chicago, Illinois 60611,4 Critical Care Department, Hospital Universitari Joan XXIII, Universitat Rovira i Virgili, Barcelona, Spain2

Received 14 August 2003/ Returned for modification 22 October 2003/ Accepted 2 December 2003

Ferroxidase (encoded by the mco gene), a component of a ferrous iron uptake pathway in Pseudomonas aeruginosa, was detected in all of the 35 respiratory clinical isolates surveyed; in contrast, considerable variation in siderophore expression was observed. The ubiquitous expression of this periplasmic ferroxidase suggests that it plays a key role in iron uptake in this opportunistic pathogen.

* Corresponding author. Mailing address: Centre for Metals in Biology, Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, 4072, Queensland, Australia. Phone: 61 7 3365 4879. Fax: 61 7 3365 4620. E-mail: jennings{at}mailbox.uq.edu.au.

Journal of Clinical Microbiology, June 2004, p. 2806-2809, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2806-2809.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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