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Journal of Clinical Microbiology, September 2004, p. 4300-4302, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4300-4302.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Potential Screening Assay for Undetectable Viruses on the Basis of Their Capacity To Induce Alpha Interferon Production

Barbara Schmidt,1 Brittany Ashlock,1 Frank Neipel,2 and Jay A. Levy1*

Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, California,1 Institute of Clinical and Molecular Virology, German National Reference Centre for Retroviruses, Erlangen, Germany2

Received 18 March 2004/ Returned for modification 28 April 2004/ Accepted 13 May 2004

High interferon production by plasmacytoid dendritic cells (PDC) was unexpectedly noted after their coculture with CD4+ cells from a healthy donor whose cells subsequently showed human herpesvirus type 6 and 7 infections. This release of interferon was not observed with uninfected normal CD4+ cells. Induction of PDC interferon production could help screen for covert virus infections.

* Corresponding author. Mailing address: Department of Medicine, Division of Hematology/Oncology, University of California School of Medicine, San Francisco, CA 94143-1270. Phone: (415) 476-4071. Fax: (415) 476-8365. E-mail: jalevy{at}itsa.ucsf.edu.

Journal of Clinical Microbiology, September 2004, p. 4300-4302, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4300-4302.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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