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Journal of Clinical Microbiology, September 2004, p. 4319-4320, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4319-4320.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibilities of Isolates of Sporothrix schenckii to Itraconazole and Terbinafine

Lidiane Meire Kohler,1 Paulo César Fialho Monteiro,2 Rosane Christine Hahn,1 and Júnia Soares Hamdan1*

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais,1 Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil2

Received 10 February 2004/ Returned for modification 29 March 2004/ Accepted 16 May 2004

Thirty isolates of the yeast form of Sporothrix schenckii were evaluated for in vitro susceptibility to itraconazole and terbinafine by the recommended NCCLS modified technique (M27-A2). The MICs of itraconazole obtained oscillated between 0.062 and 4.0 µg/ml, and those of terbinafine oscillated between 0.007 and 0.50 µg/ml; therefore, terbinafine showed greater in vitro activity.

* Corresponding author. Mailing address: Departamento de Microbiologia, ICB/ UFMG, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Phone: 55 31 3499-2758. Fax: 55 31 3499-2730. E-mail: handan{at}icb.ufmg.br.

Journal of Clinical Microbiology, September 2004, p. 4319-4320, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4319-4320.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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