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Journal of Clinical Microbiology, September 2004, p. 4365-4369, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4365-4369.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Differing Patterns of Liver Disease Progression and Hepatitis C Virus (HCV) Quasispecies Evolution in Children Vertically Coinfected with HCV and Human Immunodeficiency Virus Type 1

Sophie Canobio,1,2 Cynthia M. Guilbert,1,2 Myriam Troesch,1,2 Johanne Samson,3 Mireille Lemay,3,4 Veronique Anne Pelletier,3,4 Anne-Claude Bernard-Bonnin,3,4 Rafal Kozielski,5,{dagger} Normand Lapointe,3,4 Steven R. Martin,4,6 and Hugo Soudeyns1,2,4*

Unité d'immunopathologie virale,1 Centre maternel et infantile sur le SIDA,3 Division of Gastroenterology,6 Department of Pathology, Centre de recherche de l'Hôpital Sainte-Justine,5 Departments of Microbiology and Immunology,2 Pediatrics, Faculty of Medecine, Université de Montréal, Montreal, Canada4

Received 7 January 2004/ Returned for modification 2 March 2004/ Accepted 4 June 2004

Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children.

* Corresponding author. Mailing address: Unité d'immunopathologie virale, Centre de recherche de l'Hôpital Sainte-Justine, 3175 Côte Sainte-Catherine, Room 6735, Montréal (Québec) H3T 1C5, Canada. Phone: (514) 345-4931, ext. 3907. Fax: (514) 345-4794. E-mail: hsoudeyns{at}justine.umontreal.ca.

{dagger} Present address: Children's Health Care of Atlanta at Scottish Rite, Atlanta, GA 30342.

Journal of Clinical Microbiology, September 2004, p. 4365-4369, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4365-4369.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Martin, S. R., Lapointe, N., Soudeyns, H. (2005). Coinfection With Hepatitis C Virus and Human Immunodeficiency Virus 1 in Children: Pathogenesis and Screening. Arch Pediatr Adolesc Med 159: 598-599 [Full Text]  


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