This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kahl, B. C.
Right arrow Articles by Harmsen, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kahl, B. C.
Right arrow Articles by Harmsen, D.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2005, p. 502-505, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.502-505.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Variation of the Polymorphic Region X of the Protein A Gene during Persistent Airway Infection of Cystic Fibrosis Patients Reflects Two Independent Mechanisms of Genetic Change in Staphylococcus aureus

Barbara C. Kahl,1* Alexander Mellmann,2 Susanne Deiwick,1 Georg Peters,1 and Dag Harmsen2

Institute of Medical Microbiology,1 Institute for Hygiene, University of Muenster, Muenster, Germany2

Received 19 June 2004/ Returned for modification 13 August 2004/ Accepted 21 September 2004

Variation of the polymorphic region of the protein A gene (spa) was observed during long-term persistence of Staphylococcus aureus in the airways of 10 cystic fibrosis patients and occurred at a rate of one genetic change every 70 months. Independent mutational events were observed eight times in 142 isolates: four deletions, two duplications of repeats, and two point mutations.

* Corresponding author. Mailing address: Institute of Medical Microbiology, University Hospital of Muenster, Domagkstr. 10, 48149 Muenster, Germany. Phone: 49-251-8355381. Fax: 49-251-8355350. E-mail: kahl{at}uni-muenster.de.

Journal of Clinical Microbiology, January 2005, p. 502-505, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.502-505.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Baum, C., Haslinger-Loffler, B., Westh, H., Boye, K., Peters, G., Neumann, C., Kahl, B. C. (2009). Non-spa-Typeable Clinical Staphylococcus aureus Strains Are Naturally Occurring Protein A Mutants. J. Clin. Microbiol. 47: 3624-3629 [Abstract] [Full Text]  
  • Mainz, J G, Naehrlich, L, Schien, M, Kading, M, Schiller, I, Mayr, S, Schneider, G, Wiedemann, B, Wiehlmann, L, Cramer, N, Pfister, W, Kahl, B C, Beck, J F, Tummler, B (2009). Concordant genotype of upper and lower airways P aeruginosa and S aureus isolates in cystic fibrosis. Thorax 64: 535-540 [Abstract] [Full Text]  
  • Kuhn, G., Francioli, P., Blanc, D. S. (2007). Double-Locus Sequence Typing Using clfB and spa, a Fast and Simple Method for Epidemiological Typing of Methicillin-Resistant Staphylococcus aureus. J. Clin. Microbiol. 45: 54-62 [Abstract] [Full Text]  
  • Moodley, A., Stegger, M., Bagcigil, A. F., Baptiste, K. E., Loeffler, A., Lloyd, D. H., Williams, N. J., Leonard, N., Abbott, Y., Skov, R., Guardabassi, L. (2006). spa typing of methicillin-resistant Staphylococcus aureus isolated from domestic animals and veterinary staff in the UK and Ireland. J Antimicrob Chemother 58: 1118-1123 [Abstract] [Full Text]  
  • Jury, F., Al-Mahrous, M., Apostolou, M., Sandiford, S., Fox, A., Ollier, W., Upton, M. (2006). Rapid cost-effective subtyping of meticillin-resistant Staphylococcus aureus by denaturing HPLC.. J Med Microbiol 55: 1053-1060 [Abstract] [Full Text]  
  • Ruppitsch, W., Indra, A., Stoger, A., Mayer, B., Stadlbauer, S., Wewalka, G., Allerberger, F. (2006). Classifying spa Types in Complexes Improves Interpretation of Typing Results for Methicillin-Resistant Staphylococcus aureus.. J. Clin. Microbiol. 44: 2442-2448 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»