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Journal of Clinical Microbiology, January 2005, p. 516-519, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.516-519.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

First Isolation of Metallo-ß-Lactamase-Producing Multiresistant Klebsiella pneumoniae from a Patient in Brazil

Nilton Lincopan,1* John Anthony McCulloch,1 Cristina Reinert,1 Valéria C. Cassettari,2 Ana C. Gales,3 and Elsa M. Mamizuka1

Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas,1 Comissão de Controle de Infecção Hospitalar, Hospital Universitário, Universidade de São Paulo,2 Laboratório Especial de Microbiologia Clínica, Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal de São Paulo, São Paulo, Brazil3

Received 30 April 2004/ Returned for modification 22 June 2004/ Accepted 3 September 2004

A multiresistant Klebsiella pneumoniae isolate was taken from the blood of a 75-year-old patient with nosocomial pneumonia who developed septic shock and failed therapy with imipenem. The isolate presented an MIC of imipenem of 128 µg/ml, and the production of a metallo-ß-lactamase was confirmed by phenotypic and genotypic techniques. We here report, for the first time, the detection of a metalloenzyme (IMP-1)-producing K. pneumoniae clinical strain in Latin America. The gene responsible for this phenotype was found to be blaIMP-1, carried in a class 1 integron.

* Corresponding author. Mailing address: Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenida Professor Lineu Prestes 580, Butantã, CEP 05508-900, São Paulo SP, Brazil. Phone: 5511 3091 3663. Fax: 5511 3813 2197. E-mail: lincopan{at}usp.br.

Journal of Clinical Microbiology, January 2005, p. 516-519, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.516-519.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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