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Journal of Clinical Microbiology, October 2005, p. 5344-5347, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5344-5347.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Outbreaks in Distinct Regions Due to a Single Klebsiella pneumoniae Clone Carrying a blaVIM-1 Metallo-ß-Lactamase Gene

Alexandros Ikonomidis,1 Despina Tokatlidou,2 Ioulia Kristo,1 Danai Sofianou,2 Athanassios Tsakris,3 Paraskevi Mantzana,1 Spyros Pournaras,1* and Antonios N. Maniatis1

Department of Medical Microbiology, Medical School, University of Thessaly, Larissa,1 Department of Microbiology, Hippokration General Hospital, Thessaloniki,2 Department of Microbiology, School of Health Sciences, University of Athens, Athens, Greece3

Received 14 July 2005/ Accepted 19 July 2005

From December 2004 to March 2005, 27 Klebsiella pneumoniae clinical isolates that were positive by the imipenem-EDTA double-disk synergy test and that exhibited a single macrorestriction pattern were recovered in two distinct Greek hospitals. The isolates carried a transferable blaVIM-1 metallo-ß-lactamase gene in a class 1 integron. Reverse transcriptase PCR showed that the gene was similarly expressed in low- and high-level carbapenem-resistant isolates, indicating the existence of additional resistance mechanisms. The clonal spread of VIM-1-producing K. pneumoniae strains in distinct regions where up to now blaVIM-2 and blaVIM-4 alleles were common is worrisome.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Hospital of Larissa, Mezourlo, 411 10 Larissa, Greece. Phone: 30 6976 881203. Fax: 30 2410 682508. E-mail: pournaras{at}med.uth.gr.

Journal of Clinical Microbiology, October 2005, p. 5344-5347, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5344-5347.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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