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Journal of Clinical Microbiology, October 2005, p. 5376-5379, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5376-5379.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Fatal Pulmonary Infection Associated with a Novel Organism, "Parastreptomyces abscessus"

W. Garrett Nichols,1,2,{dagger} Jennifer Prentice,3 Yolanda Houze,3 LaDonna Carlson,3 and Brad T. Cookson3,4*

Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington,1 Medicine, Infectious Disease Division,2 Laboratory Medicine,3 Microbiology, University of Washington, Seattle, Washington4

Received 9 April 2005/ Returned for modification 16 May 2005/ Accepted 20 July 2005

Actinomycetes are increasingly recognized as pathogenic in the immunocompromised host. We isolated an asporogenous, nonmotile, aerobic gram-positive rod from a transplant recipient with a fatal pulmonary infection. The pathology was similar to that associated with Rhodococcus equi, including intrahistiocytic localization. The organism was relatively inert in standard biochemical tests. 16S rRNA gene sequencing indicated a potentially unique organism most closely related to the genus Streptomyces, for which we propose the name "Parastreptomyces abscessus."

* Corresponding author. Mailing address: Departments of Laboratory Medicine and Microbiology, University of Washington, Box 357110, Seattle, WA 98195. Phone: (206) 598-6131. Fax: (206) 598-6189. E-mail: cookson{at}u.washington.edu.

{dagger} Present address: GlaxoSmithKline, Research Triangle Park, N.C.

Journal of Clinical Microbiology, October 2005, p. 5376-5379, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5376-5379.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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