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Journal of Clinical Microbiology, November 2005, p. 5775-5778, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5775-5778.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

New Quinolone Resistance Phenomenon in Salmonella enterica: Nalidixic Acid-Susceptible Isolates with Reduced Fluoroquinolone Susceptibility

Antti J. Hakanen,1,2* Marianne Lindgren,1 Pentti Huovinen,1 Jari Jalava,3 Anja Siitonen,4 and Pirkko Kotilainen1,2

Antimicrobial Research Laboratory,1 Laboratory of Human Microbial Ecology,3 Enteric Bacteria Laboratory, Department of Bacterial and Inflammatory Diseases, National Public Health Institute, Turku and Helsinki,4 Department of Medicine, Turku University Hospital, Turku, Finland2

Received 23 June 2005/ Returned for modification 9 August 2005/ Accepted 22 August 2005

We describe the emergence of a new quinolone resistance pattern in Salmonella enterica isolates from Southeast Asia. These isolates are susceptible to nalidixic acid but exhibit reduced susceptibility to ciprofloxacin. The increase of such strains may threaten the value of the nalidixic acid disk test to screen for reduced fluoroquinolone susceptibility in salmonellas.

* Corresponding author. Mailing address: Antimicrobial Research Laboratory, National Public Health Institute, P.O. Box 57, 20521 Turku, Finland. Phone: 358-2-3316600. Fax: 358-2-3316699. E-mail: antti.hakanen{at}utu.fi.

Journal of Clinical Microbiology, November 2005, p. 5775-5778, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5775-5778.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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