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Journal of Clinical Microbiology, November 2005, p. 5784-5786, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5784-5786.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Use of Four Dengue Virus Antigens for Determination of Dengue Immune Status by Enzyme-Linked Immunosorbent Assay of Immunoglobulin G Avidity

Séverine Matheus,1 Xavier Deparis,2 Bhety Labeau,1 Josiane Lelarge,1 Jacques Morvan,1 and Philippe Dussart1*

Centre National de Référence des Arbovirus, Institut Pasteur de la Guyane, Cayenne, French Guiana,1 Epidemiology Unit, Institut Pasteur de la Guyane, Cayenne, French Guiana2

Received 18 March 2005/ Returned for modification 2 June 2005/ Accepted 24 August 2005

We used an enzyme-linked immunosorbent assay (ELISA) of immunoglobulin G avidity to determine the dengue immune status of 105 pairs of serum samples from patients infected with dengue virus. This study shows that a simple avidity test, for which only one acute-phase serum sample is required, is potentially more useful than the hemagglutination inhibition test for the discrimination of primary from secondary dengue virus infection, whatever the type of dengue antigen used.

* Corresponding author. Mailing address: Centre National de Référence des Arbovirus, Institut Pasteur de la Guyane, 23 avenue Pasteur, BP 6010, 97306 Cayenne cedex, French Guiana. Phone: 594.594.29.26.09. Fax: 594.594.29.58.09. E-mail: pdussart{at}pasteur-cayenne.fr.

Journal of Clinical Microbiology, November 2005, p. 5784-5786, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5784-5786.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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