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Journal of Clinical Microbiology, November 2005, p. 5819-5821, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5819-5821.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Molecular Identification of Rhizomucor pusillus as a Cause of Sinus-Orbital Zygomycosis in a Patient with Acute Myelogenous Leukemia

Peter C. Iwen,1* Alison G. Freifeld,2 Lynne Sigler,3 and Stefano R. Tarantolo2,{dagger}

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska,1 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska,2 University of Alberta Microfungus Collection and Herbarium, Devonian Botanic Garden, Edmonton, Alberta, Canada3

Received 12 July 2005/ Returned for modification 12 August 2005/ Accepted 27 August 2005

Sinus-orbital zygomycosis caused by Rhizomucor pusillus in a patient with acute myelogenous leukemia is described. Identification was achieved by sequencing of the internal transcribed spacer (ITS) regions of the rRNA gene and by expression of zygospores in mating. This report highlights the value of ITS sequencing as a diagnostic tool for the identification of R. pusillus and expands the understanding of infection types caused by this zygomycete.

* Corresponding author. Mailing address: Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495. Phone: (402) 559-7774. Fax: (402) 559-4077. E-mail: piwen{at}unmc.edu.

{dagger} Present address: Methodist Cancer Center, Omaha, Nebr.

Journal of Clinical Microbiology, November 2005, p. 5819-5821, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5819-5821.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Alvarez, E., Sutton, D. A., Cano, J., Fothergill, A. W., Stchigel, A., Rinaldi, M. G., Guarro, J. (2009). Spectrum of Zygomycete Species Identified in Clinically Significant Specimens in the United States. J. Clin. Microbiol. 47: 1650-1656 [Abstract] [Full Text]  
  • Stark, D., Milliken, S., Marriott, D., Harkness, J. (2007). Rhizopus microsporus var. rhizopodiformis sinus-orbital zygomycosis in an immunosuppressed patient: successful treatment with posaconazole after a complicated clinical course. J Med Microbiol 56: 699-701 [Abstract] [Full Text]  
  • Iwen, P. C., Sigler, L., Noel, R. K., Freifeld, A. G. (2007). Mucor circinelloides Was Identified by Molecular Methods as a Cause of Primary Cutaneous Zygomycosis. J. Clin. Microbiol. 45: 636-640 [Abstract] [Full Text]  


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