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Journal of Clinical Microbiology, December 2005, p. 6054-6059, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6054-6059.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Molecular Fingerprinting of Leishmania infantum Strains following an Outbreak of Visceral Leishmaniasis in Central Israel

Abedelmajeed Nasereddin,1 Gad Baneth,2 Gabriele Schönian,3 Moein Kanaan,4 and Charles L. Jaffe1*

Kuvin Centre for the Study of Tropical and Infectious Diseases, Hebrew University—Hadassah Medical School, Jerusalem, Israel,1 School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel,2 Institute of Microbiology and Hygiene, Charité University Medicine, Berlin, Germany,3 Division of Molecular Genetics, Life Science Department, Bethlehem University, Bethlehem, Palestinian Authority4

Received 21 July 2005/ Returned for modification 22 August 2005/ Accepted 15 September 2005

Human and canine visceral leishmaniasis caused by Leishmania infantum emerged in central Israel after an absence of over 30 years. The origin of this outbreak was investigated by examining genetic polymorphisms in 37 strains isolated from dogs and patients with visceral leishmaniasis in the continuously active northern Israeli and West Bank foci and in a new Israeli focus using DNA fingerprinting with the human multilocus minisatellite probe 33.15. Analysis of the patterns obtained by DNA fingerprinting separated the strains geographically into northern (clade B) and central (clades A and C) genotypic groups. These results suggest that the emergence of visceral leishmaniasis in central Israel is due not to parasite spread from northern Israel to the new focus but rather to increased parasite transmission in central Israel and the West Bank coupled with changes in the ecoepidemiology of this region.

* Corresponding author. Mailing address: Department of Parasitology, Hebrew University—Hadassah Medical School, P.O. Box 12272, Jerusalem 91220, Israel. Phone: 972-2-6757435. Fax: 972-2-6757425. E-mail: cjaffe{at}cc.huji.ac.il.

Journal of Clinical Microbiology, December 2005, p. 6054-6059, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6054-6059.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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