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Journal of Clinical Microbiology, December 2005, p. 6171-6175, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6171-6175.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Frequent Importation of Enterovirus 71 from Surrounding Countries into the Local Community of Yamagata, Japan, between 1998 and 2003

K. Mizuta,^1* C. Abiko,¹ T. Murata,¹ Y. Matsuzaki,² T. Itagaki,³ K. Sanjoh,⁴ M. Sakamoto,⁵ S. Hongo,² S. Murayama,¹ and K. Hayasaka¹

Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata, Japan,¹ Department of Infectious Diseases, Yamagata University School of Medicine, Yamagata, Japan,² Yamanobe Pediatric Clinic, Yamagata, Japan,³ Sanjoh Clinic, Yamagata, Japan,⁴ Department of Pediatrics, Yamagata City Hospital, Saiseikan, Yamagata, Japan⁵

Received 26 July 2005/ Returned for modification 6 September 2005/ Accepted 23 September 2005

Phylogenetic analysis of 45 enterovirus 71 (EV71) isolates for 6 years in Yamagata, Japan, clarified that the annual outbreak of hand-foot-and-mouth disease was due to four genetically distinct subgenogroups, including a novel "B5." Our results suggest that the importation of EV71 from surrounding countries has had a major epidemiological impact on the local community used in our study.

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* Corresponding author. Mailing address: Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1-6-6, Yamagata, 990-0031 Japan. Phone: 81-23-627-1109. Fax: 81-23-641-7486. E-mail: mizutak{at}pref.yamagata.jp.

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Journal of Clinical Microbiology, December 2005, p. 6171-6175, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6171-6175.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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