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Journal of Clinical Microbiology, December 2005, p. 6183-6185, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6183-6185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Association between Cellular Human Immunodeficiency Virus DNA Level and Immunological Parameters in Patients with Undetectable Plasma Viremia Level during Highly Active Antiretroviral Therapy

Loredana Sarmati,1 Saverio Giuseppe Parisi,6 Emanuele Nicastri,2 Gabriella d'Ettorre,4 Lucia Palmisano,5 Mauro Andreotti,5 Carolina Andreoni,4 Marina Giuliano,5 Francesca Gatti,3 Caterina Boldrin,6 Giorgio Palù,6 Vincenzo Vullo,4 Stefano Vella,5 and Massimo Andreoni1*

Department of Public Health and Cellular Biology, University of Rome Tor Vergata, Rome,1 National Institute for Infectious Diseases, IRCCS L. Spallanzani, Rome,2 Institute of Immunology and Infectious Diseases, University of Verona, Verona,3 Department of Infectious Diseases University of Rome La Sapienza, Rome,4 Istituto Superiore di Sanità, Rome,,5 Department of Microbiology, Padua University Hospital, Padua, Italy6

Received 4 April 2005/ Returned for modification 4 August 2005/ Accepted 16 September 2005

The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/106 peripheral blood mononuclear cells) had higher pre-HAART (P = 0.001) and current (P = 0.005) CD4 counts and a prolonged duration of treatment (P = 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower (P = 0.006) and undetectable (P < 0.001) HIV DNA values.

* Corresponding author. Mailing address: Department of Public Health and Cellular Biology, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. Phone and fax: (39-06) 72596873. E-mail: andreoni{at}uniroma2.it.

Journal of Clinical Microbiology, December 2005, p. 6183-6185, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6183-6185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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