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Journal of Clinical Microbiology, February 2005, p. 745-749, Vol. 43, No. 2
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.2.745-749.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-Lactamases in Dar es Salaam, Tanzania

Bjørn Blomberg,1,2,3* Roland Jureen,2 Karim P. Manji,4 Bushir S. Tamim,4 Davis S. M. Mwakagile,5 Willy K. Urassa,5 Maulidi Fataki,4 Viola Msangi,5 Marit G. Tellevik,2 Samwel Y. Maselle,1,5 and Nina Langeland2,3

Centre for International Health,1 Institute of Medicine, University of Bergen,2 Haukeland University Hospital, Bergen, Norway,3 Department of Paediatrics and Child Health,4 Department of Microbiology and Immunology, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania5

Received 27 June 2004/ Returned for modification 1 September 2004/ Accepted 11 October 2004

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.

* Corresponding author. Mailing address: Centre for International Health, University of Bergen, N-5021 Bergen, Norway. Phone: 4755974980. Fax: 4755974979. E-mail: bjorn.blomberg{at}cih.uib.no.

Journal of Clinical Microbiology, February 2005, p. 745-749, Vol. 43, No. 2
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.2.745-749.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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