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Journal of Clinical Microbiology, March 2005, p. 1456-1458, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1456-1458.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

False-Positive Histoplasma capsulatum Gen-Probe Chemiluminescent Test Result Caused by a Chrysosporium Species

Mary E. Brandt,1* Dennis Gaunt,2 Naureen Iqbal,1 Shirley McClinton,1 Sarah Hambleton,3 and Lynne Sigler4

Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 University Hygienic Laboratory, Iowa City, Iowa,2 Biodiversity Theme (Mycology and Botany), Environmental Health Team, Agriculture and Agri-Food Canada, Eastern Cereal and Oilseed Research Centre, Ottawa, Ontario,3 Microfungus Collection and Herbarium, Devonian Botanic Garden, University of Alberta, Edmonton, Alberta, Canada4

Received 8 September 2004/ Returned for modification 21 October 2004/ Accepted 26 October 2004

We describe a case in which the Histoplasma capsulatum AccuProbe test displayed cross-reactivity with a respiratory isolate thought to be Histoplasma but not morphologically consistent with H. capsulatum. The isolate was later identified as the Chrysosporium anamorph of Nannizziopsis vriesii by sequence analysis and phenotypic data.

* Corresponding author. Mailing address: Mycotic Diseases Branch, Centers for Disease Control and Prevention; 1600 Clifton Rd., Mail Stop G-11, Atlanta, GA 30333. Phone: (404) 639-0281. Fax: (404) 639-3546. E-mail: mbb4{at}cdc.gov.

Journal of Clinical Microbiology, March 2005, p. 1456-1458, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1456-1458.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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