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Journal of Clinical Microbiology, March 2005, p. 1462-1464, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1462-1464.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Adenovirus Type F Subtype 41 Causing Disseminated Disease following Bone Marrow Transplantation for Immunodeficiency

Mary A. Slatter,1 Steven Read,2 Clive E. Taylor,3 Bruce N. A. Crooks,1 Mario Abinun,1 Terence J. Flood,1 Andrew J. Cant,1 Christopher Wright,4 and Andrew R. Gennery1*

Paediatric Immunology Unit,1 Health Protection Agency, Newcastle General Hospital,3 Department of Histopathology, Royal Victoria Infirmary, Newcastle upon Tyne,4 Micropathology Ltd., University of Warwick Science Park, Coventry, United Kingdom2

Received 12 September 2004/ Returned for modification 25 October 2004/ Accepted 22 November 2004

Adenovirus causes disseminated disease following bone marrow transplantation (BMT). We report a child who underwent T-cell-depleted BMT. Adenovirus subgenus F serotype 41 was detected antemortem by PCR in cerebrospinal fluid and postmortem in other tissues. Serotypes 40 and 41, associated with gastrointestinal disease, have not previously been implicated in disseminated disease.

* Corresponding author. Mailing address: Paediatric Immunology Unit, Ward 23, Newcastle General Hospital, Westgate Rd., Newcastle upon Tyne NE4 6BE, United Kingdom. Phone: 0191 233 6161. Fax: 0191 2730183. E-mail: a.r.gennery{at}ncl.ac.uk.

Journal of Clinical Microbiology, March 2005, p. 1462-1464, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1462-1464.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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