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Journal of Clinical Microbiology, April 2005, p. 1973-1976, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.1973-1976.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Evidence for icaADBC-Independent Biofilm Development Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical Isolates

Fidelma Fitzpatrick, Hilary Humphreys, and James P. O'Gara*

Department of Clinical Microbiology, Education and Research Centre, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland

Received 14 December 2004/ Accepted 14 December 2004

Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Education and Research Centre, Smurfit Building, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland. Phone: 353-1-809 3711. Fax: 353-1-809 3709. E-mail: jogara{at}rcsi.ie.

Journal of Clinical Microbiology, April 2005, p. 1973-1976, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.1973-1976.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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